Huntington Body Rejuvenation Center
Body Rejuvenation System
- Hollywood is the Land of Dreams offering vast opportunities. However based on the fact that California is the most populated State in the US with over 38 million in population and the greater percentage of its population is now over 65 years or older. Hence it is also a state with high population of AMD- age related Macular Degeneration, which is a major cause of Retinal Degeneration of the elderly as AMD is more common in Caucasians than other races and more common in women than men and in people with blue eye.
- It is a debilitating condition affecting 19.8 million Americans and over 12.6% of the population had AMD and 1.49 million people or 0.94% of the population had vision-threatening late stage AMD) This is 2.75 times higher than previous estimates.
- Vision loss remains a stubbornly untreatable condition as every doctor will tell you there is no known cure. Vision loss - blindness is irreversible.
Treatment available
1. anti-VEGF injection The most commonly available solution currently in the market is Intravitreal injection eg. Eyelea, Lucentis, Vabysmo and Avastin. These drugs block a protein called Vascular Endothelial Growth Factor, hence the name anti-VEGF . It is used to arrest the development of abnormal blood vessels growing an under the Retina which would leak blood or fluid causing loss of vision. So injection every 4-6 weeks to slow the progression of blindness.
Complications are rare but there is risk. According to statistics, eg. VABYSMO (injection 3-4 times per year), patients has had serious, sometimes fatal, problems related to blood clots, such as heart attacks or strokes (thromboembolic events). In clinical studies for Wet AMD, during the first year, 7 out of 664 patients treated with VABYSMO reported such an event. For Clinical Studies for DME from baseline to week 100, 64 out of 1262 patients treated with VABYSMO reported such an event.
Despite the risk, anti- VEGF is still a common treatment procedure especially for wet AMD, the more advanced type of Retinal Degeneration. Clinical trials have allowed more than 90% of patients to maintain their level of vision. However in real world, the percentage is only close to 50%. The cost of monthly injection to treat wet AMD just in California alone exceeded $9 billion( single patient cost $25,000 per year)
2. Gene Therapy for wet AMD- despite the promise of Gene therapy, long term effectiveness remain to be seen. Such a treatment is likely to be very expensive even as compared to anti- VEGF. So it may not be suitable for everyone with wet AMD.
3. Stem Cell Therapy- by replacing the cells that begin to die in late stage Dry AMD. One strategy is to layer the stem cells on thin scaffoldings. Another tactic is to put the cells into a fluid suspension that can be injected under the retina. Stem cells have been tested in small clinical trials meaning long term efficacy and safety data are limited. It may take about 10-15 years for these therapy to be fine tuned and proven effective in humans. Potential side effects- while generally considered safe, potential side effects may include inflammation, retinal detachment or vision worsening in some cases.
4. BRS - a body cell rejuvenating system
An innovative approach that leverages advancements in cellular manipulation to address the degenerative processes underlying AMD. Here’s an in depth exploration of how nanomicrocurrent technology inspired by the pioneering work of Nehar and Sakmann ( the 2 German Scientists who won the 1991 Nobel Prize of Medicine & Physiology) can be applied to AMD treatment.
1. Understanding the basics:
Nano microcurrent Technology
This involves the application of extremely small electric currents at nano scale to influence cellular behavior. Nehar and Sakmann’s development of the patch clamp technique demonstrated how precise electrical control can modulate ion channel activity, thereby effecting cell membrane permeability and cellular function.
Age related Macular Degeneration
AMD is a progressive eye disease affecting the macula, the central part of the retina responsible for sharp central vision. It leads to the deterioration of photoreceptor cells and retinal pigment epithelium(RPE), resulting in vision loss. There are 2 primary forms:-
Dry AMD- characterized by the thinning of the macula and accumulation of drusen.
Wet AMD- involves abnormal blood vessel growth(neovascularization) under the retina, leading to leakage and scarring.
2. Potential Applications of Nano- Microcurrent technology in AMD
a. Modulating Retinal cell function
- photoreceptor preservation:
nano-Microcurrent can be used to enhance the survival and function of photoreceptor cells by regulating ion channels involved in phototransduction. By maintaining appropriate potassium ion K+ levels and membrane potentials, nanomicrocurrents can help sustain photoreceptor activity and delay degeneration.
- Retinal Pigment Epithelial ( RPE) support
RPE cells are crucial for photoreceptor health, providing metabolic support and phygocytosing shed photoreceptor outer segments. Nanomicrocurrent can enhance RPE cell function by modulating ion transport and reducing oxidative stress, thereby promoting a healthier retinal environment.
b. Inhibiting neovascularizationin Wet AMD
- Regulating Growth Factor Release
Nanomicrocurrent can influence the secretion of vascular endothelial growth factor(VEGF) from RPE cells. By modulatingVEGF levels, nanomicrocurrent can help prevent abnormal blood vessel growth characteristic of wet AMD.
- Direct impact on Endothelial cells
Applying nanomicrocurrent to the endothelial cells involved in neovascularization can disrupt their proliferation and migration, thereby inhibiting the formation of leaky blood vessels under the retina.
3. Mechanism of actions
a. Ion channel modulation
Nanomicrocurrent can selectively target ion channels, such as potassium K+ channels, to regulate cellular excitability and signaling pathways. In retinal cells, maintaining ionic balance is essential for phototransduction and cell survival.
b. Membrane potential stabilization
By influencing the membrane potential, nanomicrocurrent can prevent apoptotic pathways triggered by cellular stress and oxidative damage, common in AMD affected cells.
c. Reducing oxidative stress
Electrical stimulation through Nanomicrocurrent can enhance cellular antioxidant defenses, mitigating the oxidative damage that contributes to AMD progression.
4. Implementation Strategies
100% Non invasive Approach
It is by introducing Nanomicrocurrent at the 6 Biofeedback points at around the eye socket that discovered by Milly Ng, through her 30 years of clinical experience, will be able to reach the damaged cells at the retina. This at the same time will give the patient a sharp needle sensation reaching to behind the eye ball at the retina level initiating a cellular rejuvenation process. ( there is no actual needle involved. Simply a feeling from the patient in relation to the severity of the condition. Ie no needle feeling when the patient fully recovered)
5. Advantages of Nanomicrocurrent based treatment for AMD
- Targeted Action
Precise modulation of Cellular functions minimizes off- target effects and reduces the risk of adverse reactions compared to systemic therapies.
- Non invasive
it offers a non invasive alternatives to current surgical interventions and injection for wet AMD.
- Potential for Disease Modification:
Unlike treatments that only manage symptoms, nanomicrocurrent technology has the potential to alter the disease course by preserving retinal cells and preventing neovascularization.
6. Challenges and Considerations
a. Technical limitations
Developing devices capable of delivering precise Naomicrocurrents consistently and safely to the delicate retinal tissues requires advance engineering and rigorous testing.
b. Biocompatibility and Safety
As the approach is 100% non invasive, so there is no comparability issue nor safety concern.
c. Regulatory hurdles
Navigating the FDA approval process for novel medical devices involves extensive clinical trials to demonstrate safety and efficacy. As it is a non invasive Class II 510(k) medical device using lithium rechargeable battery is certainly less stringent compared to implantable device or stem cell therapy or anti- VEGF injections- which are more risky than the non invasive BRS approach.
d. Patient Acceptance
The non invasive approach and the eye ffordable price bracket should be a winner.
7. Current Research and Future Directions
While the application of Nanomicrocurrent Technology specifically to AMD is still in its nascent stages, related research provides a foundation:
Studies have explored electrical stimulation to promote retinal ganglion cell survival and function, offering insights into optimizing Nanomicrocurrent applications for AMD.
8. Conclusion
Applying Nanomicrocurrent technology to AMD treatment holds significant promise by offering a novel method to modulate cellular functions, enhance retinal cell survival, and inhibit pathological processes such as neovascularization. Leveraging the foundational principles established by Nehar and Sakmann, this approach could lead to more effective and targeted therapies for AMD, potentially improving the quality of life for millions affected by this debilitating disease. Continued interdisiplinary research and collaboration between neuroscientists, ophthalmologit’s, biomedical engineers,and regulatory bodies will be essential to translate this innovative concepts into viable clinical treatments.
9. References
1. Nehar, E., & Sakmann, B. (1991)” Single - channel currents recorded from membrane of dene frogs muscle fibers” Nature, 350(6317), 760-740.
2. Spaide, R. F.(2018). “Age related macular Degeneration” The Lancet, 392(10162), 1147-1159
3. Wikström , M. et al. (2014)” electrical stimulation promotes functional recovery of neurons after injury.” Nature Neuroscience, 17(7), 944-950.
4. Sahel B. A. , & Hassain, IT (2006)”Neuroprotection by electrical stimulation” Journal of neuroscience research, 84(4) 768-777.
Note:The application of Nanomicrocurrent technology to AMD is a highly specialized and emerging field. While the theoretical frame work is promising, actual clinical application would require extensive research, development and validation through vigorous scientific studies and clinical trials.
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- AMD - Age Related Macular Degeneration is a common cause of Blindness in United States which affected more than 1.75 million people.
- There is no known cure which means it will only get worse with age and it significantly affect the person’s quality of life.
- How wonderful to know if there is a new Med Tech that can Non Invasively Reverse Vision Loss.
BRS Biofeedback
The Science
We use a non invasive FDA regulated Medical Device - BRS biofeedback to introduce nanomicrocurrent (NMC) to our body through specific access points around the eye, which target the pathological cells in the retina to facilitate cell rejuvenation in a fraction of a second.
Career
Recruit Vison Recovery Trainee
The Training
- Sent in the application - pre- med student or nurse practitioner.
- Learn step by step how to implement the proprietary skill to become a trainee.
- Take the test to graduate as a RVL Practitioner.
- Join our platform to deliver treatment to Age homes, institutions, school of the visual impaired.
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